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An antibiotic called rifaximin has shown promise in treating irritable gut syndrome ( IBS ) in two large clinical trials by targeting bacterium in the gut , researchers encounter .
Four weeks after the beginning a two - calendar week - farsighted discussion with the drug , 41 per centum of people who took it read they had relief from theirIBS symptoms — including bloat , abdominal bother and loose and watery BM . Of those who take on the placebo , 32 percent account relief , the work show .
With " the other medications studied in the past , you have to stay on them , otherwise one hebdomad after check , you ’re back the room you were , " say study researcher Dr. Mark Pimentel , music director of the Gastrointestinal Motility Program and Laboratory at Cedars - SinaiMedical Centerin Los Angeles . But with rifaximin , " you treat it , it ’s kind of a one - and - done , for at least a stop of clip . "
Rifaximin is currently okay by the Food and Drug Administration ( FDA ) to care for traveler ’s diarrhea and hepatic brain disease , a condition that result when the liver is ineffective to remove toxic center from the line . The FDA will likely make a decision about approving rifaximin to treat IBS within the next two to three calendar month , Pimentel say .
The newfangled studies will be write tomorrow ( Jan. 6 ) in the New England Journal of Medicine . Salix Pharmaceuticals , Inc. , the manufacturing business of rifaximin , provided financial backing for the study . Pimentel is a advisor to Salix , Inc. , and serves on its scientific advisory circuit board .
Finding assuagement
IBS is one of the most common disorder in the United States , consort to the National Institute of Diabetes and Digestive and Kidney Diseases . As many as one in five Americans has the condition , which is characterized by stark cramp , bloating , constipation , looseness of the bowels and abdominal pain .
IBS can be because of excessive amount ofbacteria in the little intestine , Pimentel said . Currentmedicationsfor IBS may relieve symptoms , but to leave go relief from the experimental condition , a drug has to kill the gut bacterium that causes it .
Pimentel and his workfellow prove rifaximin in two trials with more than 600 patients in each .
The people in the trials all had IBS with modest to moderate diarrhea and bloating . Some were assign to take 550 mg of rifaximin three times a workweek for two weeks , andothers were assigned a placebo .
Pimentel say patients get relief even eight workweek after they stopped taking the drug , whereas other IBS drugs only provide relief if the affected role is currently taking the drug .
Rifaximin versus other drug
Rifaximin is dissimilar from other antibiotic one might take for a urinary nerve tract contagion or a fistula infection , Pimentel articulate . He said it less likely to createantibiotic resistancebecause 99 percent of it passes out of the physical structure in the stool , rather than being absorbed into other areas of the body outside the bowel .
People who took the drug to regale IBS also did n’t have any more or less side effects than people who took the placebo , Pimentel say .
Pass it on : The antibiotic rifaximin could shortly be approve for use in treat irritable bowel syndrome .
